DAF-16 is the sole ortholog of the FOXO family of transcription factors in the nematode Caenorhabditis elegans. [1] .

Aug 23, 2017 · And DAF-16/FOXO, as a key transcription factor, could integrate different signals from these pathways to modulate aging, and longevity via shuttling from cytoplasm to nucleus. …

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many …

In this chapter, I will focus on understanding how a single gene daf-16 can incorporate signals from multiple upstream pathways and in turn modulate different phenotypes as well as the …

Jan 9, 2020 · In C. elegans, the conserved transcription factor DAF-16/FOXO is a powerful aging regulator, relaying dire conditions into expression of stress resistance and longevity promoting …

Aug 23, 2017 · DAF-16/FOXO integrates signals from different pathways to modulate aging and longevity. Insulin-like molecules bind to DAF-2 receptor to lead to the activation of PI3P …

Identifying and functionally testing DAF-16 target genes has been a focal point of ageing research for the last 10 years. Here, I review the recent advances in identifying and understanding …

DAF-16 is the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway. Besides IIS, a number of additional signalling cascades …

Feb 17, 2019 · We found that DAF‐16 translocates into the nucleus in aged wild‐type worms and activates the expression of hundreds of genes in response to age‐associated cellular stress. …

Jan 1, 2018 · daf-16 is a central regulator for multiple biological processes. How does this one gene receive multiple inputs and then target many downstream genes to regulate these …