Cyrius uses a novel method to solve the problems caused by the high sequence similarity with the pseudogene paralog CYP2D7 and thus is able to detect all star alleles, particularly those that contain structural variants, accurately.

Several bioinformatic tools have been developed to genotype CYP2D6 from short-read sequencing data. Among these, Cyrius, a tool specifically designed for CYP2D6 genotyping, has demonstrated high performance across various datasets.

Jan 18, 2021 · Here we describe a novel bioinformatics method, Cyrius, that accurately genotypes CYP2D6 using whole-genome sequencing (WGS) data. We show that Cyrius has superior performance (96.5% concordance...

Here we describe a novel bioinformatics method, Cyrius, that accurately genotypes CYP2D6 using whole-genome sequencing (WGS) data. We show that Cyrius has superior performance (96.5% concordance with truth genotypes) compared to existing methods (84-86.8%).

Feb 3, 2025 · Among these, Cyrius, a tool specifically designed for CYP2D6 genotyping, has demonstrated high performance across various datasets. However, Cyrius has not been updated in the past 3 years, during which dozens of new star alleles have been identified and some previously defined ones revised.

May 5, 2020 · Here we describe Cyrius, a novel WGS-specific CYP2D6 genotyping tool that overcomes the challenges with the homology between CYP2D6 and CYP2D7 and works for sequence data aligned to both hg38 and hg19.

Aug 1, 2010 · This paper reviews the current understanding of the flow around two “infinite” circular cylinders of equal diameter immersed in a steady cross-flow, with a focus on the near-wake flow patterns, Reynolds number effects, intermediate wake structure and behaviour, and the general trends in the measurements of the aerodynamic force coefficients ...

May 17, 2012 · Quantifying instantaneous flow reversal of tracer particles in subsonic, transonic and supersonic flows past a circular cylinder

Cross-flow filtration is different from dead-end filtration in which the feed is passed through a membrane or bed, the solids being trapped in the filter and the filtrate being released at the other end.

May 18, 2011 · Uniform flow over a circular cylinder is known as a classical problem in the studies of bluff-body aerodynamics. For this configuration, a good wealth of data in the literature has been accumulated over a wide range of Reynolds numbers, say, 10 2 –10 7 (Roshko 1993; Zdravkovich 1997).