Cyclin A2 (Ccna2) is a key protein involved in the direction of mammalian cardiac myocytes to grow and divide, and has been shown to induce cardiac repair following myocardial infarction. …

Mar 30, 2025 · CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Bardet-Biedl Syndrome and Myeloid Leukemia . Among its related pathways are CDK …

Sep 30, 2016 · These data reveal cyclin A2 as a mechanistically diverse regulator of DNA replication combining multifaceted kinase-dependent functions with a kinase-independent, …

Aug 27, 2019 · Through structural, biochemical and in vivo analysis, we identify a non-canonical D box (D2) that is critical for cyclin A2 ubiquitination in vitro and degradation in vivo. During the …

Nov 26, 2015 · Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry.

May 17, 2019 · CyclinA2 (CCNA2) was the only CDK-regulating cyclin, which exhibited higher expression under disease conditions (Supplementary Fig. 2e, m).

From the transcription of its gene to its posttranslational modifications, cyclin A2 regulation reveals the complexity of the regulatory network shaping cell cycle progression.

Jan 5, 2021 · Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2 …

Sep 9, 2016 · Cyclin A2 activates the cyclin-dependent kinases Cdk1 and Cdk2 and is expressed at elevated levels from S phase until early mitosis. We found that mutant mice that cannot …

Alternate noncanonical roles for cyclins continue to be discovered; they have important implications for their role in cancer and metastasis. The traditional role for cyclin A2 is in the …