Importantly, cyclin C-induced mitochondrial fission was found to increase sensitivity of both mammalian and yeast cells to apoptosis. Here, we review and discuss the biology of cyclin C, focusing mainly on its transcriptional and non-transcriptional roles in …

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II.

The key cyclins involved in the cell cycle and cancer progression are cyclin D, cyclin E, cyclin A, cyclin B, and cyclin C. D type cyclins (cyclin D1/D2/D3) bind to CDK4 and CDK6, which are essential for the cell to enter the G1 phase [17].

Oct 26, 2014 · Cyclin C was cloned as a growth-promoting G 1 cyclin, and was also shown to regulate gene transcription. Here we report that in vivo cyclin C acts as a haploinsufficient tumour suppressor, by...

Here we report that in vivo cyclin C acts as a haploinsufficient tumor suppressor, by controlling Notch1 oncogene levels. Cyclin C activates an “orphan” CDK19 kinase, as well as CDK8 and CDK3. These cyclin C-CDK complexes phosphorylate Notch1 intracellular domain (ICN1) and promote ICN1 degradation.

Nov 1, 2020 · Alteration of cell cycle cyclin levels is a common feature of human cancer. Proper progression throughout the cell division cycle depends on the expression level of a family of proteins known as cyclins, and the subsequent activation of cyclin-dependent kinases (Cdks).

Oct 6, 2014 · The conserved C-type cyclin plays an important role in executing this molecular Rubicon by coupling changes in gene expression to mitochondrial fission and PCD. Cyclin C, along with its cyclin dependent kinase partner Cdk8, associates with the RNA polymerase holoenzyme to regulate transcription.

Jan 4, 2019 · Importantly, cyclin C-induced mitochondrial fission was found to increase sensitivity of both mammalian and yeast cells to apoptosis. Here, we review and discuss the biology of cyclin C, focusing mainly on its transcriptional and non-transcriptional roles …

Jan 27, 2014 · As cyclin C undergoes proteosomal degradation in the cytosol, cyclin C was only transiently localized to mitochondria. Despite its short life on mitochondria, cyclin C performed an important role in promoting mitochondrial division.

Apr 26, 2022 · Cyclin C (encoded by the CCNC gene) is a highly conserved nuclear protein and makes an entry into to cell cycle in the form of cyclin C/Cdk3 complexes as key regulators. 6 Upon oxidative stress, cyclin C is recruited from nuclei to mitochondria and promotes mitochondrial division and apoptosis of the yeast cell. 7 A cDNA microarray‐based ...