Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase of the cell cycle.

Mar 30, 2025 · CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Laryngeal Squamous Cell Carcinoma and Pancreatic Adenocarcinoma. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Mitotic G1 …

Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle [2] until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present). [3]

Jan 15, 2008 · Cyclin B1 is a key regulatory protein controlling cell cycle progression in vertebrates. Cyclin B1 binds CDK1, a cyclin-dependent kinase catalytic subunit, forming a complex...

Cyclin B1 is a key mitotic cyclin in the G2-M phase transition of the cell cycle and is overexpressed in various malignant tumors. Numerous studies have reported contradictory evidences of the correlation between cyclin B1 expression and prognosis in human solid tumors.

These results demonstrate that nuclear translocation mediates the biological activity of cyclin B1 and suggest that phosphorylation within the CRS domain of cyclin B1 plays a regulatory role in this process.

Cyclin B1 and its catalytic partner CDK1 belong to the fundamental kinase machinery regulating the progression from G2 to mitosis. Also known as the mitotic promoting factor (MPF), cyclin B1/CDK1 phosphorylation governs key steps for mitotic entrance featured by the nuclear envelope breakdown, spindle formation, and chromatin condensation [56].

Sep 6, 2024 · Cyclin B1 (CCNB1) encodes a regulatory protein essential for the regulation of cell mitosis, particularly in controlling the G2/M transition phase of the cell cycle.

Feb 8, 2025 · Expression of Cyclin B1 correlated with differentiation and vascular invasion in NSCLC; Cyclin B1 overexpression associated with higher mean values for Ki-67 proliferative index and proliferating cell nuclear antigen labeling index and poorer prognosis.

Feb 4, 2008 · At mitotic entry, cyclin B1-CDK1 promotes chromosome condensation, nuclear lamina resolution and mitotic spindle assembly while cyclin B2-CDK1 can only induce Golgi disassembly.