NADPH oxidase 2 (Nox2), also known as cytochrome b (558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).

May 13, 2020 · Here, we report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4 + T cells through LC3-associated phagocytosis (LAP).

Apr 22, 2023 · The CYBB maintained a high ROS state to sustain the mesenchymal phenotype, TMZ resistance, and reduced erastin sensitivity. Mechanistically, CYBB interacted with Nrf2 and consequently regulated SOD2 transcription.

Apr 13, 2020 · To identify differentially expressed ROS and antigen-presenting genes in single-cell clusters, we compared expression of the pro-oxidant gene Cybb, which encodes the nicotinamide adenine ...

Apr 30, 2024 · Our study shows that CYBB is strongly correlated with clinical characteristics features and prognosis of glioma patients, and can be used as a potential therapeutic target. Prognostic models based on CYBB and mitochondrial genes have good performance in predicting prognosis of glioma patients.

The CYBB maintained a high ROS state to sustain the mesenchymal phenotype, TMZ resistance, and reduced erastin sensitivity. Mechanistically, CYBB interacted with Nrf2 and consequently regulated SOD2 transcription.

Dec 7, 2018 · We identified cytochrome b-245 heavy chain (CYBB), a gene encoding a reactive oxygen species (ROS)-generating enzyme, to be important for human M1 macrophage polarization, which supports previous findings of oxidative stress as a critical regulator of macrophage function.

The membrane bound NADPH oxidase involved in the synthesis of reactive oxygen species (ROS) is a multi-protein enzyme encoded by CYBA, CYBB, NCF1, NCF2 and NCF4 genes. Growing evidence suggests a role of ROS in the modulation of signaling pathways ...

Chronic granulomatous disease (CGD) is characterized by defects in the production of microbicidal reactive oxygen species (ROS) by phagocytes. Testing of gene and cell therapies for the treatment of CGD in human hematopoietic cells requires preclinical transplant models.

Apr 1, 2024 · In our study, high magnification immunofluorescence shows colocalization of CYBB and CD163 molecules in lepromatous leprosy lesion macrophages, and M leprae has a pronounced effect on host-cell ferroptosis by influencing the expression level of ROS in vitro.