Aug 30, 2024 · Ultimately, CTSH was identified as the key ECM-related biomarker. CTSH was associated with difference immune cells during the occurrence and development of DFU, and it influenced hedgehog, IL-17 and TNF signaling pathway.

Mar 9, 2024 · Ultimately, CTSH was identified as the key ECM-related biomarker. CTSH was associated with difference immune cells during the occurrence and development of DFU, and it influenced hedgehog, IL-17 and TNF signaling pathway. Additionally, CTSH expression is correlated with many ECM- and immune-related genes.

Apr 20, 2018 · In this Review, we summarize the available evidence implicating cysteinyl cathepsins in the pathogenesis of cardiovascular diseases, discuss their potential as biomarkers of disease progression,...

We propose that CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin activation and adhesion strength. Tumor metastases represent a major oncological clinical problem and are a leading cause of death in cancer patients.

Cathepsin H (Ctsh) encodes for serine protease, which was shown to increase the expression of MMP genes through the degradation of histone deacetylases (HDACs) . Interestingly, Plat and Plaur, two genes involved in plasmin activation, are regulated in opposite directions.

Nov 24, 2015 · CTSZ-deficient PanNET cancer cells show impaired proliferation and decreased adhesion to ECM proteins; for example, fibronectin, collagen and the reconstituted ECM mixture Matrigel 25.

Mar 6, 2013 · Cathepsins play a role in ECM remodelling, with cathepsin D, H and K (CTSD, CTSH and CTSK) being associated with lung diseases. CTSD modulates the NC1 domains of collagen molecules including tumstatin, while CTSH and CTSK are involved in ECM degradation.

Apr 13, 2022 · Mechanistic studies showed that only glycosylated CTSV (43-kDa band) are secreted to extracellular matrix (ECM) and promoted the metastasis of lung cancer.

Aug 29, 2024 · Ultimately, CTSH was identified as the key ECM-related biomarker. CTSH was associated with difference immune cells during the occurrence and development of DFU, and it influenced hedgehog,...

Apr 1, 2017 · Western blot analysis demonstrated a tight inverse association between the increased CtsH and down-regulation of HDAC4 by the cells in 3D ECM (Figure 4 E), further suggesting that cysteine-type cathepsins are HDAC4-degrading enzymes.