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High CS1 (SLAMF7) expression on myeloma cells and limited expression on normal cells makes it a promising target for CAR-T therapy. The CS1 protein has two extracellular domains – the …

Nov 15, 2022 · Bispecific CS1-BCMA CAR-T cells are effective in targeting MM cells in preclinical studies (Biomedicines 2021). Here we report the outcomes of 16 pts with refractory or …

In this study, we aimed to develop novel CS1 CAR-T cells and bispecific CS1-BCMA CAR-T cells to specifically target multiple myeloma. We generated a new CS1 (CD319, SLAM-7) antibody, …

Oct 17, 2023 · Bispecific CAR-T cell therapy has been proposed to mitigate some limitations of single-target CAR-T cells. CS1, also known as CD319, SLAMF7, and CRACC, is a cell …

In this study, we determined whether CS1, a surface protein that is highly expressed on MM cells, can be targeted by CAR NK cells to treat MM. We successfully generated a viral construct of a …

The MM.1S human myeloma cell line (CS1+; expressing luciferase and GFP; MM.1S-CG) were used as target cells in four hour Chromium 51 release killing assays. At a 10:1 effector: target …

May 8, 2020 · Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable clinical efficacy against B-cell malignancies, yet marked vulnerability to antigen escape and tumor …

Apr 14, 2022 · High CS1 (SLAMF7) expression on myeloma cells and limited expression on normal cells makes it a promising target for CAR-T therapy. The CS1 protein has two …

Mar 1, 2019 · CS1-CAR-Ts expressing the scFv derived from Elotuzumab antibody (clone HuLuc63) show efficacy in preclinical myeloma models. Here, we report testing of CS1-CAR …