Complement regulatory proteins in kidneys of patients with anti ...
The study aimed to investigate the expression of complement regulatory proteins (CRPs) CD46, CD55 and CD59 in kidneys of 51 AVV patients. The expression of CD46, CD55 and CD59 in …
Bispecific mAb2 Antibodies Targeting CD59 Enhance the …
Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer …
Expression of complement regulatory proteins [membrane cofactor protein ...
May 1, 2003 · Our results suggest that under stress, the high expression of CRPs (CD46, CD55, and CD59) could protect endometrial injured cells against complement mediated lysis. The …
Bispecific mAb2 Antibodies Targeting CD59 Enhance the
May 6, 2022 · The manifold functions and ubiquitous expression of CRPs preclude their systemic specific inhibition. We selected CD59-specific Fc fragments with a novel antigen binding site …
Overexpression of Human CD55 and CD59 or Treatment with …
Jun 15, 2017 · Complement activation on intact self cells is tightly regulated by a number of circulating and membrane-bound complement regulatory proteins (CRPs). Two key membrane …
COMPLEMENT REGULATION IN RENAL DISEASE MODELS - PMC
Proteins which prevent formation of C5b-9 include plasma clusterin and S protein, and cellular CD59. The complement inhibitory properties of all these CRPs are conferred by their fairly low …
Generation of 1E8 Single Chain Fv-Fc Construct Against Human CD59
Dec 1, 2012 · Among the CRPs, human protectin (CD59) is an 18~25-kDa glycoprotein that is linked to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. CD59 inhibits …
C-reactive protein upregulates the whole blood expression of CD59 …
Sep 18, 2017 · Strikingly, our computational analysis and cell culture stimulation assays revealed increased CRP levels to drive the expression of complement regulatory protein CD59, …
Expression of complement regulatory proteins [membrane
Our results suggest that under stress, the high expression of CRPs (CD46, CD55, and CD59) could protect endometrial injured cells against complement mediated lysis. The survival of …
The membrane complement regulatory protein CD59 and its …
Aug 5, 2019 · CD59 is a membrane complement regulatory protein that inhibits the formation of the terminal complement complex or membrane attack complex (C5b6789n) which is …