Jan 20, 2010 · Subcutaneous injection of the peptide endothelin-1 (ET-1) into the rat's footpad is known to cause rapid, transient ipsilateral mechanical and thermal sensitization and nocifensive hind paw flinching.

The contralateral paw is located in the opposite side of the 6-OHDA unilateral injection. For example, the left paw is considered contralateral when 6-OHDA is injected in the right brain hemisphere. Unilateral lesion of the striatum with 6-OHDA causes preferential use of the forelimb ipsilateral paw (the paw in the same side of the lesion).

These results demonstrate that long-term inhibition of the ACC neurons contralateral to the CCI is required to relieve MIP in the uninjured hind paw of CCI mice, reflecting a slow effect of the ACC neurons contralateral to the CCI on regulating MIP.

Apr 22, 2020 · Hind paw withdrawal thresholds were determined as a measure of ipsilateral and contralateral mechanosensitivity for chronic sciatic nerve ligation (SN-CL) and sham (SH) female rats by the Simplified Up-and-Down Order (SUDO) method, which is more recently developed.

Like the Hargreaves test, the thermal probe test permits measurement of ipsilateral and contralateral paw withdrawal temperatures, which is advantageous in unilateral pain models, such as carrageenan-induced inflammation, burns injury and capsaicin-induced thermal hypersensitivity.

Contralateral hyperalgesia, occurring after unilateral injury, is usually explained by central sensitization in spinal cord and brain. We previously reported that injection of endothelin-1 (ET-1) into one rat hindpaw induces prolonged mechanical and chemical sensitization of …

We previously reported that injection of endothelin-1 (ET-1) into one rat hindpaw induces prolonged mechanical and chemical sensitization of the contralateral hindpaw. Here, we examined the role of contralateral efferent activity in this process.

2 days ago · Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were used as indicators of hyperalgesia. The immunofluorescence staining was employed to detect the expression of c-Fos in ACC and identify the subtypes of co-labeled c-Fos+ neurons. ... PWT and PWL in the contralateral hind-paw of the CIBP group were not different at 7 d, 14 d and ...

Ipsilateral and contralateral paw withdrawal threshold in response to a mechanical allodynia, b cold allodynia, c mechanical hyperalgesia and d thermal hyperalgesia in chronic constriction...

Thus, 5-HT 1/2A/2C/3 receptors contribute to the effect of serotonin in the activity of a descending pathway that facilitates the response of spinal neurons to noxious inputs induced by a surgical incision in the contralateral paw. Finally, the increase in the number of Fos-LI neurons in lamina X was significantly inhibited by LY 278,584 ...