Apr 1, 2018 · Congo red: ordinary light imparts a pink to red color to amyloid deposits; the beta pleated sheet structure of amyloid produces an apple green birefringence under polarized microscopy when stained by Congo red or sirius red stain PAS: moderately positive

Mar 1, 2018 · Calcitonin, CEA, TTF1 (weak to moderate), PAX8 (variable and weak) (Mod Pathol 2008;21:192), Congo red for amyloid Calcitonin gene related peptide, ACTH, somatostatin, gastrin releasing peptide, neurotension, low molecular weight keratin, chromogranin A and B, synaptophysin, neuron specific enolase, progesterone receptors (Mod Pathol 1996;9:68)

Apr 14, 2021 · Colon, splenic flexure, biopsy: Amyloidosis (see comment) Comment: The biopsy shows amorphous eosinophilic material present around submucosal blood vessels. On Congo red stain, the material demonstrates apple green birefringence.

Apr 27, 2020 · Congo red special stain shows apple green birefringence upon polarization, supporting the diagnosis. The specimen will be sent for mass spectrometry for amyloid typing and these results will be issued as an addendum.

Jul 18, 2022 · Confirmation with Congo red staining and polarization of amyloid showing typical apple green birefringence Thicker tissue sections (8 - 10 microns) are helpful in visualizing the polarized deposits

Jan 9, 2024 · A cardiac biopsy demonstrates negative Congo red staining and there is a well founded morphologic suspicion for cardiac amyloidosis. What is the next best step? Abdominal fat pad biopsy Crystal violet stain Provide the negative diagnosis and suggest alternative diagnoses Repeat Congo red stain on 2 more sections

Nov 9, 2020 · Tubulovillous adenoma (see comment) Comment: The submucosa adjacent to tubular adenoma contains prominent hyalinized, homogenously eosinophilic, amorphous ribbons and globules with foreign body giant cells, scattered eosinophils and fibrosis consistent with lifting agent granuloma. Congo red stain is negative for amyloid.

6 days ago · Immunostains, routine stains and CD markers at PathologyOutlines.com

Apr 14, 2022 · Light microscopy shows pale nodular expansion of the mesangium of the glomeruli which is weak PAS positive and silver and trichrome negative and Congo red stain positive, while immunofluorescence shows positive staining of glomeruli and interstitial vessel walls for lambda light chain and negative staining for all other immunoreactants ...

Oct 18, 2021 · Light chain proximal tubulopathy (see comment) Comment: Cytoplasmic accumulation of monoclonal kappa or lambda light chain (as the case may be) in the proximal tubules as confirmed by immunofluorescence fulfils criteria for LCPT diagnosis. Light microscopy and EM support the diagnosis. Congo red stain is negative.