C5a is a protein fragment released from cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments.

Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b: C5a plays an important role in chemotaxis. [6] C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease.

Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury.

Complement receptor C5a (C5aR, CD88) recognizes the anaphylatoxin C5a which is the most powerful of the group. It is distributed on neutrophils, monocytes, and other leukocytes, as well as numerous nonmyeloid cells.

The complement-activated product, C5a, displays powerful biological activities that lead to inflammatory sequelae.

The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg.

May 10, 2020 · Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2.

HUVECs express complement anaphylatoxin-binding receptors C3aR and C5aR1. Relative levels of RNA transcripts of C3aR (A) and C5aR1 38 are shown as determined from RNA extracts isolated from endothelial cells stimulated with purified C3a or C5a, in comparison to untreated controls. Values are represented as mean ± SE analyzed from three independent experiments run in duplicate test wells, and ...

Feb 17, 2023 · The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1 (C5aR1) and associated downstream G protein and β-arrestin signaling pathways.

Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury.