A functionally defined high-density NRF2 interactome reveals new ...
Verification and conditional stratification of 46 new NRF2 partners was achieved by co-immunoprecipitation and the novel integration of quantitative data from dual luminescence …
MiR-28 regulates Nrf2 expression through a Keap1-independent …
Nrf2 function is regulated post-translationally by its negative regulator Kelch-like ECH-associated protein 1 (Keap1) that binds Nrf2 and induces cytoplasmic Nrf2 degradation. Our present …
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing ...
Dec 17, 2021 · NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles and oxidation, promotes …
The Keap1–Nrf2 pathway: promising therapeutic target to counteract …
The Keap1–Nrf2 system acts as a double-edged sword: Nrf2 activity protects cells and makes the cell resistant to oxidative and electrophilic stresses, whereas elevated Nrf2 activity helps in …
PPIA dictates NRF2 stability to promote lung cancer ... - Nature
Jun 3, 2024 · Here, we identify peptidylprolyl isomerase A (PPIA) is required for NRF2 protein stability. Ablation of PPIA promotes NRF2 protein degradation and blocks NRF2-driven growth …
SIRT6 as a key event linking P53 and NRF2 counteracts APAP …
Jan 1, 2021 · Sirt6 knockdown significantly prevented APAP-induced NRF2 activation, reduced the transcriptional activities of GSTμ and NQO1 and the mRNA levels of Nrf2, Ho-1, Gstα and …
Caffeic acid ameliorates metabolic dysfunction-associated …
Nov 1, 2024 · CA could directly bind to kelch-like ECH-associated protein 1 (Keap1) that is an Nrf2 inhibitor protein. This study suggests that CA alleviates MASLD by reducing hepatic lipid …
Transcription factor Nrf2 regulates SHP and lipogenic gene …
Oct 7, 2010 · Nuclear factor erythroid-2 related factor 2 (Nrf2) plays a pivotal role in cytoprotection against both endogenous and exogenous stresses. Here, we establish a novel molecular link …
Identification of novel NRF2-regulated genes by ChIP-Seq ... - PubMed
To identify human NRF2-regulated genes, we conducted chromatin immunoprecipitation (ChIP)-sequencing experiments in lymphoid cells treated with the dietary isothiocyanate, sulforaphane …
Regulation of notch1 signaling by nrf2: implications for tissue ...
Jul 13, 2010 · Notch1 regulates processes such as proliferation and cell fate decisions. We report a functional role for this cross talk between the two pathways and show that disruption of Nrf2 …