Cohesin is a protein complex that mediates sister chromatid cohesion, homologous recombination, and DNA looping. Cohesin is formed of SMC3, SMC1, SCC1 and SCC3 (SA1 or SA2 in humans). Cohesin holds sister chromatids together after DNA replication until anaphase when removal of cohesin leads to separation of sister chromatids. The complex forms ...

Cohesin is particularly important in meiotic cells to hold bivalents together during homologous recombination and DSB repair. Whether cohesin is actively recruited to sites of DSBs during meiosis, as it is in mitotic cells, is not well known.

Mar 22, 2021 · Beyond its originally discovered role tethering replicated sister chromatids, cohesin has emerged as a master regulator of gene expression. Recent advances in chromatin topology resolution and single-cell studies have revealed that cohesin has a pivotal role regulating highly dynamic chromatin interactions linked to transcription control.

The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

Jun 18, 2018 · Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. In this Primer, Makrantoni and Marston summarise the molecular functions and regulation of cohesin that underlie its central role in chromosome segregation during mitosis.

Nov 15, 2008 · Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore …

Loss of cohesin leads to the disappearance of loop domains and to a closer correspondence between genome compartmentalization patterns and histone modification patterns.

Cohesin regulates expression of genes that control differentiation, morphogenesis, proliferation, and pluripotency. The cohesin complex consists of the Smc1, Smc3, Rad21 and Stromalin (SA)/Stag2 subunits . Cohesin is thought to bind by encircling DNA, and binding requires the Nipped-B/NIPBL – Mau-2 complex, and ATPase activity in the Smc1 and ...

3 days ago · Here, we document that cohesin-associated protein precocious dissociation of sisters 5A (Pds5A) plays a noncanonical role in the meiotic spindle assembly during oocyte maturation independent of its cohesion function. Pds5A distributes on the spindle fibers in oocytes at both metaphase I and metaphase II stages. Morpholino-based depletion or ...

Aug 1, 2012 · This pairing function between the duplicated genome is primarily provided by a multimeric protein complex, called cohesin. Thus, genome integrity largely depends on cohesin as it ensures faithful chromosome segregation by holding the sister chromatids glued together from S phase to anaphase.