Jun 5, 2019 · Here, we report the development of highly operational light-sensitive ChRs by optimizing the kinetics of a recently reported ChR variant, Chloromonas oogama (CoChR). In …

Nov 1, 2022 · Recent large-scale transcriptome sequencing revealed one potent optogenetic actuator, the channelrhodopsin from species Chloromonas oogama (CoChR), which …

Oct 14, 2019 · ChRger2 enables light-induced neuronal excitation without fiber-optic implantation; that is, this opsin enables transcranial optogenetics. ChRs are light-gated ion channels found in...

Chrimson is a new red-light drivable channelrhodopsin with spectra 45 nm more red-shifted than any previous channelrhodopsin. Together, Chronos and Chrimson robustly mediate the …

CoChR and ChR2-mediated activation of TRN leads to similar habituation patterns. To further compare CoChR- and ChR2-expressing animals, we evaluated whether both opsins yielded …

Codon-optimized versions of Chrimson and CoChR were designed for C. elegans and expressed in different mechanosensory neurons. Freely moving animals produced robust behavioral …

Channelrhodopsin-2 (ChR2), the first widely adopted optogenetic tool, is also a blue light activated cation channel. ChR2 is preferred over ChR1 because ChR2 has higher conductance at …

Here, we report the development of highly operational light-sensitive ChRs by optimizing the kinetics of a recently reported ChR variant, Chloromonas oogama (CoChR). In particular, we …

Conclusions: CoChR exhibits higher light sensitivity compared to the ChR2 mutants of comparable kinetics. Its light sensitivity and temporal properties can be further optimized by …

Nov 13, 2017 · We designed a high-efficacy soma-targeted opsin, finding that fusing the N-terminal 150 residues of kainate receptor subunit 2 (KA2) to the recently discovered high …