CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene. [5][6] It is a part of the CCR4-Not complex, which deadenylates mRNAs. [7] CNOT1 acts …

Mar 30, 2025 · Complete information for CNOT1 gene (Protein Coding), CCR4-NOT Transcription Complex Subunit 1, including: function, proteins, disorders, pathways, orthologs, and expression.

In this study, we addressed the function of the CNOT1 subunit by depleting its expression in HeLa cells. Flow cytometric analysis revealed that the sub G (1) fraction was increased in CNOT1 …

The CNOT1 gene encodes a subunit of the CCR4-NOT complex, which has an important role in posttranscriptional regulation. CCR4-NOT is the main enzyme responsible for mRNA …

The largest subunit, CNOT1 (Not1 in yeast), serves as the backbone of the CCR4-NOT complex and interacts with most other core subunits to form distinct structural and functional modules. …

Feb 9, 2025 · Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. Depletion of CNOT1 induces cell …

Jul 2, 2020 · We report on 39 individuals with heterozygous de novo CNOT1 variants, including missense, splice site, and nonsense variants, who present with a clinical spectrum of …

Here, we show that three members of the Ccr4-Not complex, Cnot1, Cnot2, and Cnot3, play critical roles in maintaining mouse and human ESC identity as a protein complex and inhibit …

May 5, 2019 · CNOT1 is one of at least nine components of the CCR4-NOT complex, which has an important role in posttranscriptional regulation and is conserved from yeast to mammals. 4 …

In this study, we addressed the function of the CNOT1 subunit by depleting its expression in HeLa cells. Flow cytometric analysis revealed that the sub G 1 fraction was increased in CNOT1 …