CLU is an extracellular molecular chaperone which binds to misfolded proteins in body fluids to neutralise their toxicity and mediate their cellular uptake by receptor-mediated endocytosis. …

Jan 21, 2025 · Clusterin (CLU) is a glycoprotein that exists in various forms in cells, including nuclear, cytoplasmic, and secreted types. The relative molecular weight of CLU varies …

Clusterin (CLU), also known as apolipoprotein J (APOJ), has been established as the third most prominent genetic risk factor for LOAD after apolipoprotein E (APOE) and bridging integrator 1 …

Feb 1, 2021 · Clusterin was first associated with Alzheimer’s disease because of the chaperone activity that the secreted isoform presents. It is an important player in clearing misfolded …

In the last years, clusterin, a challenging and paradoxical apolipoprotein, has been of growing interest amongst a rising number of scientists. This enigmatic protein is present in all fluids of …

Feb 28, 2019 · Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer’s disease (AD).

Clusterin is a multifaceted glycoprotein abundant in the nervous system that contributes to neuroprotection and remodeling after CNS injury. It has potential therapeutic implications for …

Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to …

Feb 8, 2021 · Clusterin (CLU) was the first reported secreted mammalian chaperone and impacts on serious diseases associated with inappropriate extracellular protein aggregation.

Clusterin (CLU) is a glycoprotein that exists in various forms in cells, including nuclear, cytoplasmic, and secreted types. The relative molecular weight of CLU varies significantly due …