Jun 30, 2023 · The stringent definition of the term clonotype is a unique antigen receptor gene rearrangement nucleotide sequence corresponding to a population of identical cells. Sub …

Clonotyping can be used to monitor clonal expansion following antigen exposure, and to compare similarities and differences in antibody repertoires within and between different subjects.

A TCR clonotype is a unique nucleotide sequence that arises during the gene rearrangement process for that receptor. The combination of nucleotide sequences for the surface expressed …

Mar 12, 2025 · Clonotypes, defined by unique antigen receptor sequences in T and B lymphocytes, arise through tightly regulated genetic mechanisms. At the core of this process is …

Jan 21, 2016 · We consider the lifetime of a T cell clonotype, the set of T cells with the same T cell receptor, from its thymic origin to its extinction in a multiclonal repertoire.

The clonotype definition based on distance requires a threshold value definition to allow the separation into close related receptor sequences, which are interpreted as clonal related.

Jan 7, 2022 · Here, we present the human Antigen Receptor database (huARdb), a large-scale human single-cell immune profiling database that contains 444 794 high confidence T or B …

Feb 13, 2019 · Clonotype definitions. We defined a V3J clonotype by the amino acid sequence of the CDR3, along with the V and J germline gene assignment.

Dec 1, 2019 · Here we review some of the experimental and theoretical approaches that have been used to estimate the number of distinct clonotypes in TCR and Ig repertoires, in naive, …

The stringent definition of the term clonotype is a unique antigen receptor gene rearrangement nucleotide sequence corresponding to a population of identical cells. Sub-clonotypes arise in …