The claudin gene family: expression in normal and neoplastic tissues
The claudin (CLDN) genes encode a family of proteins important in tight junction formation and function. Recently, it has become apparent that CLDN gene expression is frequently altered in …
The claudin–transcription factor signaling pathway - PMC
We discuss the functional relevance of phosphotyrosine motifs in the C-terminal cytoplasmic domain of CLDNs and define mutual regulation between CLDNs and Src-family kinases …
Claudins: from gatekeepers of epithelial integrity to potential …
Claudins, a family of tetraspan transmembrane proteins, are critical to the integrity of tight junctions in epithelia and endothelia, influencing cellular processes such as development, …
Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment
The 24 claudin (<i>CLDN</i>) genes in the human genome encode 26 representative CLDN family proteins. CLDNs are tetraspan‑transmembrane proteins at tight junctions. Because …
Morphologic determinant of tight junctions revealed by claudin-3 ...
Feb 18, 2019 · In the Cldn family, the residue of the TM3 thenar is either proline, glycine, or alanine, and the TM3 structure would determine the orientation of the ECD like that of our …
The claudin-transcription factor signaling pathway - PubMed
Jul 3, 2021 · We discuss the functional relevance of phosphotyrosine motifs in the C-terminal cytoplasmic domain of CLDNs and define mutual regulation between CLDNs and Src-family …
Structure and Function of the Claudin Family - BPS Bioscience
Claudins (encoded by the multi-gene family CLDN) are tetraspan membrane proteins found in all epithelial and endothelial cells. They serve as crucial structural components of tight junction …
Claudin-23 reshapes epithelial tight junction architecture to …
Oct 5, 2023 · Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal tract, barrier …
The claudin gene family: expression in normal and neoplastic …
Jul 12, 2006 · The claudin (CLDN) genes encode a family of proteins important in tight junction formation and function. Recently, it has become apparent that CLDN gene expression is …
An overview of the human claudin family members from …
Claudin-6 (CLDN6) is one of the 27 family members of claudins and majorly involved in the tight junction and cell-to-cell adhesion of epithelial cell sheets, playing a significant role in...