Jun 2, 2016 · Early biochemical and microscopic studies revealed the existence of chromatin domains and loops as a pervasive feature of interphase chromosomes, but the biological …

We propose here that the essential feature of the chromatin domains is that they perpetuate through mitosis and are conserved among different cell lineages in animals. We discuss the …

Nov 26, 2024 · We discuss the universality of spatial chromatin domains in all kingdoms, each encompassing one to several genes. We also highlight differences between organisms and …

Jul 6, 2018 · Studies in higher eukaryotes show that the only heritable chromatin domains comprise trimethylation of H3K9 (H3K9me3) and of H3K27 (H3K27me3), which are associated …

Apr 1, 2025 · In eukaryotic cells, chromatin forms loops that collapse into chromatin domains and serve as functional units of the genome. Chromatin domains vary in physical properties based …

Recent studies suggest that each chromosome is comprised of many distinct chromatin do-mains, referred to variably as topological domains or topologically associating domains (TADs), that …

We demonstrated that nucleosomes form compact domains with a peak diameter of ∼160 nm and move coherently in live cells. The heterochromatin-rich regions showed more domains and …

3 days ago · When we investigated the 3D architecture following the insertion, we observed the formation of a chromatin interaction domain across the region which in combination with the …

Apr 1, 2005 · Chromatin domains are defined by distinct sets of post-translationally modified histones. Recent studies show that these histone modifications are also involved in …

Recent chromosome-conformation-capture studies have revealed topologically-associating domains (TADs) as a conserved feature of chromatin organization, but how TADs are spatially …