Orbitofrontal control of visual cortex gain promotes visual …
Jun 3, 2020 · To examine how OFC top-down projection influences V1 neuronal responses, we expressed excitatory opsin Channelrhodopsin-2 (ChR2) or ChrimsonR in the OFC, and …
Orbitofrontal and striatal circuits dynamically encode the shift ...
Aug 6, 2013 · We identify a role for orbitofrontal cortex (OFC) in actions following outcome revaluation, and confirm that dorsal medial (DMS) and lateral striatum (DLS) mediate different …
Huang et al. report that the ventrolateral orbitofrontal cortex (vlOFC) modulates sensory components of neuropathic pain in mice. They show that activation of excitatory thalamic …
Orbitofrontal Cortex Neurons Respond to Sound and Activate …
Jan 9, 2017 · We injected AAV2-ChR2-YFP into OFC and after a survival time of several weeks inserted a linear 16-channel electrode array into A1 that allowed us to record responses …
Serotonergic projections to the orbitofrontal and medial prefrontal ...
We found that serotonergic activation promotes waiting for delayed rewards most effectively in the OFC. OFC stimulation is as effective as DRN photostimulation when reward timing is invariant, …
High-efficiency channelrhodopsins for fast neuronal stimulation at …
ChR2 (T159C), which we refer to as “ChR2-TC” or simply “TC,” generates very large photocurrents and sensitizes neurons to very low light intensities. The E123T/T159C double …
Repeated Cortico-Striatal Stimulation Generates Persistent ... - Science
Jun 7, 2013 · To determine the specificity of OFC-VMS pathway hyperactivation in induction of persistent grooming, we injected AAV-ChR2 into infralimbic and prelimbic cortex (IL/PrL) (fig. …
Stress induces insertion of calcium-permeable AMPA receptors in the OFC ...
May 18, 2020 · To isolate OFC–amygdala synaptic transmission, we injected an AAV vector expressing a ChR2-EYFP fusion protein under the control of a CaMKIIα promoter into the …
Orbital frontal cortex updates state-induced value change for
Jun 13, 2018 · Recent hypotheses have posited that orbital frontal cortex (OFC) is important for using inferred consequences to guide behavior. Less clear is OFC’s contribution to goal …
The Mechanism of the Channel Opening in Channelrhodopsin-2: A …
Mar 16, 2023 · Channelrhodopsin-2 (ChR2) has been one of the most important objects in the study of optogenetics. The retinal chromophore molecule absorbs photons and undergoes an …