Dec 15, 2010 · Postsynaptic depolarization induced by ChR2 can be combined with two-photon glutamate uncaging to potentiate visually identified dendritic spines. ChR2-mediated …

Two critical findings helped overcome this limitation. First, the discovery that transfecting mammalian neurons with algae-derived light-sensitive ion channel channelrhodopsin-2 …

Dec 31, 2006 · We have combined millisecond activation of channelrhodopsin-2 (ChR2), a light-gated ion channel, with two-photon calcium imaging to investigate active synaptic contacts in …

In a random sample of 12 MSNs, we measured ChR2-and ChrimsonR-EPSC kinetics and found no statistical differences between the two groups, with ChR2-EPSCs decay being 7.72 ± 0.42 …

Oct 1, 2014 · ChR2-assisted circuit mapping (CRACM) of inhibitory inputs. CRACM is a powerful tool for functional mapping of neural circuits and long-range connections using ChR2 photo …

Feb 21, 2020 · We have engineered a simple yet versatile model for assessing neural plasticity by co-culturing channelrhodopsin (ChR2)-expressing glutamate neurons with non-ChR2 …

Feb 9, 2022 · For ChAT-ChR2 experiments, EPSC charge was calculated as the integral of the trace in a window of 65 ms starting with photostimulation. EPSC peak amplitude was …

Mar 5, 2018 · We used ChR2-assisted circuit mapping (CRACM) to examine neuronal/compartmental excitatory and inhibitory synaptic balance (E-I balance) in pyramidal …

We show that transient, physiologically consequential in-creases in extracellular potassium ions accompany ChR2 optogenetic excitation. This coincidental effect may be important to consider …

Jun 1, 2016 · To investigate excitatory and inhibitory GABA actions in cortical neuronal networks, we present a novel optogenetic approach using a mouse knock-in line with conditional …