Chemerin is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1 (also known as ChemR23). Chemerin is a 14 kDa protein secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases .

Chemerin is a novel adipokine that plays a major role in adipogenesis and lipid metabolism. It also induces inflammation and affects insulin signaling, steroidogenesis and thermogenesis. Consequently, it likely contributes to a variety of metabolic and cardiovascular diseases, including atherosclerosis, diabetes, hypertension and pre-eclampsia.

Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Chemerin message is regulated by nuclear receptor agonists, ...

Chemerin, encoded by the gene Rarres2, is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism. In humans, local and circulating levels of chemerin are positively correlated with BMI and obesity-related biomarkers.

Chemerin, encoded by the gene retinoic acid receptor responder 2 (Rarres2), also known as tazarotene-induced gene 2 (TIG2), was recently identified as one of the adipokines with autocrine, paracrine and even endocrine roles in vivo (Rourke et al. 2013).

Aug 7, 2022 · As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C-C motif chemokine receptor-like 2, CCRL2).

Chemerin (RARRES2 or TIG2) is a recently discovered chemoattractant protein that serves as a ligand for the G protein-coupled receptor CMKLR1 (ChemR23 or DEZ) and has a role in adaptive and innate immunity.

Chemerin, also known as retinoic acid receptor responder protein 2, is a 14-kDa protein secreted in an inactive form, named prochemerin, which is then activated through cleavage of its C-terminus by serine proteases. Apart from its role in adipogenesis and adipocyte metabolism, chemerin is a chemoattractant for professional APCs, dendritic ...

Mar 29, 2023 · Chemerin is a multifaceted adipokine that is involved in multiple biological processes, including inflammation, angiogenesis, adipogenesis, and energy metabolism, as well as oxidative stress. There is a vast body of evidence for a crucial role of chemerin in the development of different cardiovascular diseases.

Feb 1, 2023 · Chemerin is an inflammatory chemokine, originally identified as a novel retinoic acid response gene in psoriatic skin lesions, with immunomodulatory effects, and recently identified as one of the adipokines with autocrine, paracrine and even endocrine effects in the body.