Moreover, as in ICC cells, AG120 ± IFNγ treatment of murine mIDH1 glioma models reactivated Cgas and Sting mRNA and protein expression and induced downstream cGAS-STING–related signaling (i.e., Ifnb1 and Cxcl10) (Fig. 4E and fig. S5G).

Mar 13, 2025 · The established EBV-positive ICC cell lines revealed enhanced immunogenicity driven by cGAS-STING pathway activation, providing valuable models for future research and insights into the mechanisms of improved immunotherapy sensitivity in EBVaICC.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated.

Preliminary exploration revealed that the immune responsiveness of EBV-positive ICC may arise from cGAS-STING pathway activation, which induces type I interferon signaling, enhances CD8+ T cell chemotaxis and promotes cytotoxic effects on tumor cells.

Invitrogen Anti-cGAS Polyclonal, Catalog # PA5-121188. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Paraffin) (IHC (P)) and ELISA (ELISA) applications. This antibody reacts with Human samples.

84045-1-RR targets cGAS in WB, IF/ICC, ELISA applications and shows reactivity with mouse samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

29958-1-AP targets cGAS in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.