CFPAC-1 cells show no effect of cAMP agonists, adenyl cyclase stimulators or phosphodiesterase inhibitors on Cl- flux, but do respond to Ca++ ionophores with increase Cl- efflux. The cells have the most common form of the CF mutation, deletion of three nucleotides resulting in the absence of phenylalanine at position 508.

It is likely that the CFPAC-1 pancreas cancer cell line may have resulted from unique molecular events that may not be representative of the basic pathogenesis which characterizes the majority of pancreas cancer cases.

Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Orthotopic …

We established a pancreatic adenocarcinoma cell line (CFPAC-1) from a patient with cystic fibrosis (CF) and assessed some of its properties. The cells show epithelial morphology and express cytokeratin and oncofetal antigens characteristic of pancreatic duct cells.

Apr 8, 2021 · CFPAC-1 cells were used as the positive control and HPNE cells as the negative control. Cell populations with high mutant frequencies were selected and seeded in 96-well plates with limiting...

CFPAC-1 is a ductal pancreatic adenocarcinoma derived by differential trypsinisation of explant cultures from a metastatic lesion in the liver of a 26 year old caucasian male with cystic fibrosis (CF).

Jan 5, 2022 · Cell information for CFPAC-1. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

CFPAC-1 is a ductal pancreatic adenocarcinoma derived by differential trypsinisation of explant cultures from a metastatic lesion in the liver of a 26 year old caucasian male with cystic fibrosis (CF).

Pancreatic Carcinoma Cell Lines - CFPAC-1

Oct 23, 2013 · Our results suggest the applicability of disulfiram as an anti-CSC agent that could possibly improve the efficacy of standard chemotherapies against PDAC. The following human cell lines were used: CFPAC-1, MIA PaCa-2, PANC-1, and AsPc-1 (pancreatic cancer cell lines); hTERT-HPNE (normal pancreatic ductal epithelial cell line).