CDKAL1 (Cdk5 regulatory associated protein 1-like 1) is a gene in the methylthiotransferase family. The complete physiological function and implications of this have not been fully determined. CDKAL1 is known to code for CDK5, a regulatory subunit-associated protein 1. [5]

Mar 30, 2025 · CDKAL1 (CDKAL1 Threonylcarbamoyladenosine TRNA Methylthiotransferase) is a Protein Coding gene. Diseases associated with CDKAL1 include Type 2 Diabetes Mellitus and Maturity-Onset Diabetes Of The Young. Among its related pathways are tRNA processing and Processing of Capped Intron-Containing Pre-mRNA.

Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused on the function of Cdkal1 as a tRNA Lys modifier and downstream effects of Cdkal1 loss on pro-insulin translational fidelity in …

Cdkal1 is an Endoplasmic Reticulum (ER) membrane bound protein and member of methylthiotransferase (MTTase) family of the radical S-adenosylmethionine superfamily, having distinct role in catalyzing the conversion of C-H to C-SCH 3 (addition of thiomethyl group).

Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused on the function of Cdkal1 as a tRNA Lys modifier and downstream effects of Cdkal1 loss on pro-insulin translational fidelity in …

It is reported that a tRNA‐modifying methylthiotransferase CDKAL1 promotes cancer stem‐like cells (CSC)‐factor SALL2 synthesis by assembling the eIF4F translation initiation complex. CDKAL1 expression is upregulated in patients with worse prognoses and is essential for maintaining CSCs in rhabdomyosarcoma (RMS) and common cancers.

Feb 9, 2025 · Variants in cdkal1 gene have been reproducibly associated with decreased first-phase insulin secretion and development of type 2 diabetes. CDKAL1 is involved in the pathogenesis of T2 diabetes through impaired beta-cell function.

Feb 8, 2024 · Enables N6-threonylcarbomyladenosine methylthiotransferase activity. Acts upstream of or within maintenance of translational fidelity and tRNA methylthiolation. Located in rough endoplasmic reticulum. Is expressed in olfactory epithelium and testis. Used to study type 2 diabetes mellitus.

Cdkal1 catalyzes methylthiolation of t6A37 in tRNALysUUU to ms2t6A37. Our results identify CDKAL1 as novel negative regulator of adipocyte differentiation and provide insights into the link between CDKAL1 and metabolic diseases such as type 2 diabetes and obesity. Cdkal1 is necessary for normal mitochondrial morphology and function in adipose ...

Oct 14, 2014 · CDKAL1 is a methylthiotransferase that catalyzes 2-methylthio modification of N(6)-threonyl-carbamoyladenosine to produce 2-methylthio-N(6)-threonyl-carbamoyladenosine at position 37 of tRNA-lys (anticodon UUU) (see TRK-TTT3-4, 189918).