Mar 30, 2025 · CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3) is a Protein Coding gene. Diseases associated with CDK5RAP3 include Beukes Hip Dysplasia and Renal Cysts And Diabetes Syndrome. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin binding.

Mar 30, 2025 · Interaction with CDK5RAP3 protects both proteins against ubiquitination and degradation via the proteasome (PubMed:20164180). ( O94874-UFL1_HUMAN) Phosphorylated at Ser-462 by ATM, enhancing protein ligase activity and promoting ATM activation in a positive feedback loop (PubMed:30886146).

Mar 30, 2025 · CDK5RAP1 (CDK5RAP1 Mitochondrial TRNA Methylthiotransferase) is a Protein Coding gene. Diseases associated with CDK5RAP1 include Peripheral Neuropathy With Variable Spasticity, Exercise Intolerance, And Developmental Delay and Inflammatory Bowel Disease 19.Gene Ontology (GO) annotations related to this gene include protein kinase binding and transferase activity.

Mar 30, 2025 · CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. May form a complex with CDK5R1 and CDK5 (By similarity). Interacts with pericentrin/PCNT; the interaction is leading to centrosomal and Golgi localization of CDK5RAP2 and PCNT (PubMed:20466722).

Mar 30, 2025 · Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity.

Complete information for ENSG00000264701 gene (RNA Gene), Novel Transcript, Antisense To CDK5RAP3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Mar 30, 2025 · Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with NOP53; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (PubMed:27323397).

Showing 25 of 1,686 results for CDK5RAP3 Search Time: 0 ms in Aliases & Descriptions Drugs & Compounds Disorders Text-Mined Disorders Domains Expression in Human Tissues Function Genomics Localization Orthologs Paralogs Pathways Phenotypes Proteins Publications Summaries Transcripts Variants in category Protein Coding RNA Gene Functional ...

Complete information for CDK5RAP3P1 gene (Pseudogene), CDK5RAP3 Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Symbol Description Category UniProt ID GIFtS GC id Score; 1: SP2-DT: SP2 Divergent Transcript: RNA Gene (lncRNA) 5: GC17M093733: 16.26: 2: SP2-AS1: SP2 Antisense RNA 1