Cdk5 is able to form a complex with p25 (cleavage peptide of p35): Cdk5/p25. P25 will lead to the hyperactivity of Cdk5. The result of the formation of this complex is the apoptosis of nerve cells and neuroinflammation. This discovery could be used to treat Parkinson's disease.

Nov 1, 2022 · Despite the fact that the small atypical serine/threonine cyclin-dependent kinase 5 (Cdk5) is expressed in a number of tissues, its activity is restricted to the central nervous system due to the neuron-only localization of its activators p35 and p39.

Mar 21, 2001 · CDK5 plays an indispensable role in the central nervous system, and its deregulation is involved in neurodegeneration. We report the crystal structure of a complex between CDK5 and p25, a fragment of the p35 activator.

Cyclin-dependent kinase-5 (Cdk5) substrates in brains with neurodegenerative diseases. In a neurodegenerative brain disease, there is Caplain cleavage in the N-terminal region of p35 to a more stable isoform p25, forming a CDK5/p25.

We generated transgenic mice to express p25, the N-terminally truncated p35 activator of cdk5, in forebrain under tetracycline control (TET-off). Neuronal expression of p25 (p25 ON) caused high mortality postnatally and early in life.

Dec 9, 1999 · To be activated, Cdk5 has to associate with its regulatory subunit, p35. We have found that p25, a truncated form of p35, accumulates in neurons in the brains of patients with Alzheimer's...

Nov 1, 2022 · The present review highlights the pivotal roles of the hyperactive Cdk5-p25 complex activity in contributing to the development of Alzheimer's disease pathogenesis, with a particular emphasis on the linking function between Aβ and tau that this kinase fulfils and on the fact that Cdk5-p25 is part of a deleterious feed forward loop giving rise ...

Jan 18, 2012 · The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown to contribute to the pathogenesis in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD).

May 11, 2001 · CDK5 plays an indispensable role in the central nervous system, and its deregulation is involved in neurodegeneration. We report the crystal structure of a complex between CDK5 and p25, a fragment of the p35 activator.

Oct 20, 2014 · We report here that p25 but not p35, the normal cyclin-like activator of CDK5, unexpectedly binds to GSK3β in the AXIN-binding region. The binding of p25 increases GSK3β activity and alters its substrate specificity.