Cdk5 Nde1 - Search

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Cell cycle-dependent ubiquitylation and destruction of NDE1 by …
CDK5, a kinase active in G1/G0, primes NDE1 for FBW7-mediated recognition. Cells depleted of FBW7 or CDK5 show enhanced levels of NDE1 and a reduction in ciliary length, which is …
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Cell cycle‐dependent ubiquitylation and destruction of NDE1 by CDK5 ...
oncotarget.com
Biological functions of CDK5 and potential CDK5 targeted clinical ...
mdpi.com
Cancers | Free Full-Text | The Role of CDK5 in Tumours and Tumour ...
researchgate.net
Model for the CDK5-Dependent Regulation of Transport through Ndel1 ...
embopress.org
Cell cycle‐dependent ubiquitylation and destruction of NDE1 by CDK5 ...
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Cell cycle-dependent ubiquitylation and destruction of NDE1 by …
Oct 1, 2015 · Cells depleted of FBW7 or CDK5 show enhanced levels of NDE1 and a reduction in ciliary length, which is corrected in cells depleted of both FBW7 or CDK5 and NDE1. These …
- Author: Dipak Maskey, Matthew Caleb Marlin, Seokho Kim, Sehyun Kim, E-Ching Ong, Guangpu Li, Leonidas Tsioka...
- Publish Year: 2015
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
NDE1 and NDEL1 from genes to (mal)functions: parallel but …
The role of NDE1 in blocking cilia growth is regulated by CDK5, with phosphorylation of NDE1 at T191 on entry to G1 phase of the cell cycle leading to its degradation and facilitating ciliogenesis .
Studies of Cdk5 Nde1
PubMed
Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length
Primary cilia start forming within the G1 phase of the cell cycle and continue to grow as cells exit the cell cycle (G0). They start resorbing when cells re-enter the cell cycle (S phase) and are practically invisible in mitosis. The mechanisms by which cilium biogenesis and disassembly are coupled ...
Author: Dipak Maskey
Published: 2015/10/01
Keywords: CDK5; FB…
National Center for Biotechnology Information
The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system
Nde1 (red) is localised to the GFAP-positive (green) stem cell of the subventricular zone of the lateral ventricle, and its overexpression in neural stem cells promotes neuronal differentiation while inhibiting astroglial differentiation. Open in a separate window Abbreviations: ...
Author: Z. Pei, B. Lang…
Published: 2014/06/06
Publication: Neuroscie…
National Center for Biotechnology Information
Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length
Primary cilia start forming within the G1 phase of the cell cycle and continue to grow as cells exit the cell cycle (G0). They start resorbing when cells re-enter the cell cycle (S phase) and are practically invisible in mitosis. The mechanisms by which cilium biogenesis and disassembly are coupled ...
Author: Dipak Maskey…
Published: 2015/10/10
Publication: EMBO J. …
National Center for Biotechnology Information
Stress-induced CDK5 activation disrupts axonal transport via Lis1/Ndel1/dynein
Axonal transport is essential for neuronal function, and defects in transport are associated with multiple neurodegenerative diseases. Aberrant cyclin dependent kinase 5 (CDK5) activity, driven by the stress-induced activator p25, is also observed in these diseases. Here, we show that elevated CDK5 ...
Author: Eva Klinman, …
Published: 2015/07/07
DOI: 10.1016/j.celrep.2…
Molecular Biology of the Cell
https://www.molbiolcell.org › doi
The Role of Nde1 phosphorylation in interkinetic …
Sep 20, 2024 · We then performed an in vitro kinase assay with recombinant Cdk5 and detected a 90% decrease in Nde1 phosphorylation in the NDE1 S214F schizophrenia mutation. Phosphorylation was assessed by quantitative …
EMBO Press
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Cell cycle-dependent ubiquitylation and - EMBO Press
CDK5,a kinase active in G1/G0, primes NDE1 for FBW7-mediated recogni-tion. Cells depleted of FBW7 or CDK5 show enhanced levels of NDE1 and a reduction in ciliary length, which is …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
The expression and roles of Nde1 and Ndel1 in the adult …
Jun 6, 2014 · In addition, Ndel1 can be phosphorylated by Aurora A kinase at position S251 or by the Cdk1/Cdk5 kinase at positions T219/T245, which are important for the interaction with …
- Author: Z. Pei, B. Lang, Y.D. Fragoso, K.D. Shearer, L. Zhao, P.J.A. Mccaffery, S. Shen, Y.Q. Ding, C.D. McC...
- DOI: 10.1016/j.neuroscience.2014.04.031
- Publish Year: 2014
- Publication: Neuroscience. 2014 Jun 20; 271(100): 119-136.
People also ask
Does CDK5 phosphorylation of NDEL1 regulate dynein binding?
Cdk5 phosphorylation of Ndel1 regulates Ndel1’s ability to bind dynein and promotes dynein’s association with microtubules (Hebbar et al., 2008; Klinman and Holzbaur, 2015; Klinman et al., 2017). Cdc2, Erk1, and Erk2 activity increase association between Ndel1 and Lis1 (Yan et al., 2003).
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated
frontiersin.org
Does NDE1 depletion prevent dynein-driven nucleokinesis?
Nde1/Ndel1 depletion prevents dynein-driven nucleokinesis, resulting in slow migration velocities and increased distance between the centrosome and nucleus (right) (Shu et al., 2004; Youn et al., 2009; Doobin et al., 2016). (D) Retrograde trafficking mediated by dynein promotes the juxta-nuclear localization of the Golgi (green) (top).
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated
frontiersin.org
Are NDE1 & NDEL1 binding well characterized?
Nde1 and Ndel1 and Lis1 binding is well-described and well-characterized (McKenney et al., 2010; Efimov and Morris, 2000; Wang and Zheng, 2011; Derewenda et al., 2007; Tarricone et al., 2004; Feng et al., 2000).
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated
frontiersin.org
Does NDE1 promote diverse dynein functions?
Nde1 Promotes Diverse Dynein Functions through Differential Interactions and Exhibits an Isoform-specific Proteasome Association. MBoC 29 (19), 2336–2345. doi:10.1091/mbc.E18-07-0418 Moon, H. M., Youn, Y. H., Pemble, H., Yingling, J., Wittmann, T., and Wynshaw-Boris, A. (2014).
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated
frontiersin.org
Does NDE1 bind to dynein?
Despite relatively high conservation with Ndel1 in the proposed binding site, purified Nde1 and dynein motor domain do not bind in vitro (Figure 2) (McKenney et al., 2010). Finally, Nde1 (amino acids 200–203) binds directly to the dynein light chain, LC8 (Stehman et al., 2007; McKenney et al., 2011).
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated
frontiersin.org
Does cdk5-fbw7 regulate ciliary length?
Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p.
Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP8…
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Cell cycle‐dependent ubiquitylation and destruction of …
Jul 23, 2015 · CDK5, a kinase active in G1/G0, primes NDE1 for FBW7-mediated recognition. Cells depleted of FBW7 or CDK5 show enhanced levels of NDE1 and a reduction in ciliary length, which is corrected...
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Cell cycle-dependent ubiquitylation and destruction of NDE1 by …
Oct 1, 2015 · CDK5, a kinase active in G1/G0, primes NDE1 for FBW7-mediated recognition. Cells depleted of FBW7 or CDK5 show enhanced levels of NDE1 and a reduction in ciliary …
Frontiers
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Nde1 and Ndel1: Outstanding Mysteries in Dynein …
Apr 12, 2022 · To modulate ciliary length, Nde1 protein levels are tightly controlled during G1/G0 and CDK5 phosphorylation of Nde1 ultimately promotes its proteasomal degradation (Maskey et al., 2015). The role of dynein in this …
nih.gov
https://www.ncbi.nlm.nih.gov › pmc › articles
Stress-induced CDK5 activation disrupts axonal transport via …
Jul 7, 2015 · Transport disruption induced by aberrant CDK5 activation depends on the Lis1/Ndel1 complex, which directly regulates dynein activity. CDK5 phosphorylation of Ndel1 …
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