CDK5: Key Regulator of Apoptosis and Cell Survival
CDK5 was first identified by Hellmich and coworkers as a neuronal cdc2-like kinase (nclk) [2] due to its ability to phosphorylate the lysine–serine–proline (KSP) motif of neurofilaments in vitro and shares 58% and 61% amino acid …
Cyclin-dependent kinase 5 - Wikipedia
Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial role in the regulation of the cell cycle.
The gene Cdk5 contains 12 exons in a region that contains around 5000 nucleotides (5kb), as it was determined by Ohshima after cloning the Cdk5 ge…Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 9 mins
Biological functions of CDK5 and potential CDK5 …
CDK5 can be mapped to chromosome 7q36 and its expression is upregulated by the transcription factors Fos and CREB through the MEK/ERK pathway and by δFosB [11, 12]. CDK5 plays a vital role in the central nervous system but has …
- Studies of Cdk5 Kirc
Expression of CDK5 in cancer - Summary - The Human Protein Atlas
Expression of CDK5 (PSSALRE) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Favorable Immunotherapy Plus Tyrosine Kinase Inhibition …
Immunotherapy (IO) plus tyrosine kinase inhibitor (TKI) has become the first-line treatment for advanced renal cell carcinoma, despite the lack of prognostic biomarkers. Cyclin-dependent …
Downregulation of PPA2 expression correlates with poor …
Sep 6, 2021 · Multivariate Cox regression analysis showed that PPA2 expression was an independent prognostic factor in patients with KIRC. Gene set enrichment analysis suggested …
- Author: Wenbiao Zhu, Huiming Jiang, Shoucheng Xie, Huanqin Xiao, Qinghua Liu, Nanhui Chen, Pei Wan, Shanming...
- DOI: 10.7717/peerj.12086
- Publish Year: 2021
- Publication: PeerJ. 2021; 9: e12086.
- People also ask
CDK5: an oncogene or an anti-oncogene: location location location
Nov 23, 2023 · CDK5 mostly acts as an oncogene, but in gastric cancer, it is a tumor suppressor due to its unique nuclear localization. This indicates that CDK5’s access to certain nuclear …
Elevated CDK5R1 expression associated with poor prognosis ...
Dec 1, 2022 · Increased CDK5R1 expression was linked to the poor prognosis in patients with bladder cancer (BLCA), breast cancer (BRCA), colorectal cancer (COAD), kidney cancer …
Cyclin-dependent kinase 5 acts as a promising biomarker in clear …
Jul 16, 2019 · CDK5 has been demonstrated to stabilize HIF-1α in hepatocellular carcinoma, which is also one of the most vascularized tumors. We hypothesize whether CDK5 has the …
Study Finds Unexpected Role for Odd-Man-Out …
Oct 9, 2024 · Dana-Farber researchers have found that CDK5, previously thought unrelated to cell division, plays a critical role in mitosis. The study shows that CDK5 is produced in excess in fast-growing cancer cells, presenting a …
Related searches for Cdk5 Kirc
