CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. [5][6][7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes …

Mar 28, 2025 · CDC34 (Cell Division Cycle 34, Ubiquitin Conjugating Enzyme) is a Protein Coding gene. Diseases associated with CDC34 include Three M Syndrome 1. Among its related …

Feb 9, 2025 · Cdc34 is a functional target of let-7 and that let-7 induces down-regulation of Cdc34, stabilization of the Wee1 kinase, and an increased fraction of cells in G (2)/M in …

Jul 24, 2019 · Cdc34 is an E2 that plays a key role in regulating cell cycle progression and requires unique structural elements to function. The molecular basis by which Cdc34 engages …

Forced expression of CDC34 promotes, whereas knockdown of CDC34 inhibits, NSCLC cell proliferation in vitro and in vivo. CDC34 competes with c-Cbl to bind Y1045 to inhibit …

CDC34 competes with c-Cbl to bind Y1045 to inhibit polyubiquitination and degradation of EGFR. In EGFR-L858R and EGFR-T790M/Del (exon 19)-driven lung tumor growth in mouse models, …

Nov 18, 2010 · CDC34 was identified as a gene essential for cell viability and the initiation of DNA replication in the yeast Saccharomyces cerevisiae (G oebl et al. 1988). The Cdc34 protein is …

Apr 7, 2024 · Title: Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy. Systematic identification of CDC34 that functions to stabilize EGFR and promote lung …

Jun 14, 2007 · CDC34 encodes a ubiquitin-conjugating enzyme (Ubc/E2) that catalyzes Skp1-Cullin-F-box (SCF) ubiquitin protein ligase -mediated substrate ubiquitination (8, 11, 12).

The Cdc34 (Ubc3) ubiquitin-conjugating enzyme from Saccharomyces cerevisiae plays an essential role in the progression of cells from the G1 to S phase of the cell division cycle. …