Jul 30, 2020 · Conventional dendritic cells (cDCs) comprise two subsets, type 1 (cDC1) and type 2 (cDC2). Plasmacytoid DCs (pDCs) are specialized for type I interferon (IFN) secretion. Every …

In fission yeast, both G 2 ‐M and G 1 ‐S transitions are triggered by activity of a single protein kinase, cdc2 (or cdc28p in budding yeast). In higher eukaryotes, multiple cyclin‐dependent …

Recent studies revealed that type-2 conventional dendritic cells (cDC2s) play an important role in antitumor immunity by promoting cytotoxic T-cell responses and helper T-cell differentiation.

Feb 1, 2025 · Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T …

Apr 7, 2023 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins …

Nov 19, 2019 · Classical dendritic cells are classified as cDC1 and cDC2 on the basis of their function and dependence on transcription factors. In Cell, Rudensky and colleagues describe …

Accumulating evidence shows that cdc2 not only promotes G(2)-M transition but is also capable of regulating G(1) progress and G(1)-S transition via association with multiple interphase cyclins; …

A subtype of conventional dendritic cells, cDC2, are able to prime CD4+ T cells for antitumor functions and the presence of cDC2 in human cancer samples may serve as a predictive …

Jan 3, 2022 · Our findings provide novel insights into the lineage commitment of cDC2, and the CD115 + Ly6C + CDPs may serve as a potential target for modulating cDC2 differentiation …

Conventional dendritic cells (cDCs) comprise two subsets, type 1 (cDC1) and type 2 (cDC2). Plasmacytoid DCs (pDCs) are specialized for type I interferon (IFN) secretion. Every subset …