Pan-cancer analysis showed that CD8A was highly associated with TMB, stemness and MSI among several tumor types including BCa (Supplementary Figure S1F–I). We further …

Using a combination of Thymic Leukemia (TL) antigen tetramer, which directly binds CD8αα, anti-CD161, and anti-Vα7.2 antibodies we have been able for the first time to clearly define CD8αα …

CD8+ T cells are required for the establishment of antitumor immunity, and their substantial infiltration is associated with a good prognosis. However, CD8+ T cell subsets in the tumor …

Jul 22, 2024 · Here we show in multiple mouse leukaemia models that high infiltration of leukaemic cells in bone marrow (BM) stimulates the transition of CD8 + CD44 + CD62L + …

Mar 13, 2024 · We find that cDC1 are required to generate broad CD8 responses against a range of diverse neoAgs. DC-therapy promotes immunogenicity of weaker neoAgs and strongly …

Aug 11, 2022 · CD8A encodes the CD8 alpha chain of αβT cells, which has been proposed as a quantifiable indicator for the assessment of CD8 + cytotoxic T lymphocytes (CTLs) recruitment …

Dec 14, 2021 · Here, a comprehensive immunogenomic analysis based on multi-omics data was performed to investigate the clinical significance and tumor heterogeneity between CD8 + T …

The T cell reinvigoration correlated with response to pembrolizumab; however, this variable itself strongly correlated with the TMB, suggesting that an effective T cell response may not be …

Nov 17, 2021 · In the current study, based on integrating molecular omics data and real‐world pharmaco‐vigilance, we found that the combination of tumour mutational burden (TMB), CD8 …

Immune checkpoint blockade (ICB) therapy targeting cytotoxic T-lymphocyte-associated protein 4, pro-grammed death 1, and programmed death ligand 1 has shown durable remission and …