T-cell surface glycoprotein CD8 alpha chain (C luster of D ifferentiation 8a), is a protein encoded by CD8A gene. [5] The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

Mar 28, 2025 · CD8A (CD8 Subunit Alpha) is a Protein Coding gene. Diseases associated with CD8A include Immunodeficiency 116 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are TCR Signaling (Qiagen) and Network map …

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell - antigen interactions.

Feb 8, 2025 · Title: Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS). Induced CD8alpha identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation.

Gene ID: 925, updated on 8-Feb-2025. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

Apr 1, 2002 · These two papers provide compelling evidence that the CD8αα homodimer and CD8αβ heterodimer are truly different in their functions, at least in mice. It is noteworthy that a TL homologue has not been found in humans, and so the question remains as to whether these findings apply to human CD8. 1. Moody, A.M ...

CD8A is a novel indicator for predicting the prognosis and immunotherapeutic response in BCa. A radiomics signature has the potential to preoperatively predict the expression of CD8A in BCa patients. Keywords: bladder cancer, CD8A, MRI, radiogenomics, immunotherapy, prognosis. 1. …

Sep 17, 2024 · Clinical resource with information about CD8A, Susceptibility to respiratory infections associated with CD8alpha chain mutation, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. ... show less

Inconsistent with a coreceptor function, CD8aa decreases antigen sensitivity of the TCR, and it can be transiently or permanently expressed on T cells, regardless of the MHC restriction of the TCR or the presence of conventional coreceptors. Together, these observations indicate that CD8aa on. cell activation.