Jan 15, 1994 · CD7 on human NK cells was found to be a signal-transducing molecule with a rapid increase in cytoplasmic free calcium observed on binding of anti-CD7 mAb to the surface of NK cells. Cross-linking of CD7 induced expression of surface activation molecules such as CD25, CD71, HLA-DR, CD69, and CD54.

Aug 30, 2022 · In the present study we observed reduced intensity of CD7 on NK cells in HIV patients. In addition, we also observed a small population of CD7 − CD2 + cells enriched in these subjects. While CD7 negative cells have been reported, others have suggested these may represent myeloid lineage cells.

Nov 26, 2009 · Here, novel subsets of peripheral blood CD3/14/19 neg NK cells and monocyte/dendritic cell (DC)–like cells were identified on the basis of CD7 and CD4 expression. Coexpression of CD7 and CD56 differentiates NK cells from CD56 + monocyte/DC-like cells, which lack CD7.

Our work examines whether treatment with CD7-targeting CAR T cells could lead to intolerable toxicity and, if so, whether we could circumvent this by deleting the CD7 gene from HSCs to generate T and NK cells lacking CD7 expression but still capable of host protection.

Jan 15, 1994 · CD7 on human NK cells was found to be a signal-transducing molecule with a rapid increase in cytoplasmic free calcium observed on binding of anti-CD7 mAb to the surface of NK cells. Cross-linking of CD7 induced expression of surface activation molecules such as CD25, CD71, HLA-DR, CD69, and CD54.

Selective elimination of CD7+ T cells and NK cells with a novel anti-CD3/CD7 immunotoxin prevented cytotoxic cell-induced myofibroblast contraction and activation and stabilised disease progress in a severely affected SSc patient who was treated on compassionate use.

Nov 14, 2020 · Objective: To analysis the expression of CD7 in NK/T-cell lymphoma as well as study the correlations between CD7 and clinical survival and prognosis. Methods: The clinical and pathological indicators of 112 NKTCL patients who were admitted to or consulted at the First Affiliated Hospital of Zhengzhou University between May 2008 and December ...

Jun 24, 2022 · This study attempts to elucidate the comprehensive immunophenotypic landscape of NK cells, including T-series universal markers (CD2, sCD3, CD4, CD5, CD7, and CD8), NK lineage-specific markers (CD16, CD56), differentiation markers (CD94, CD57), activation markers (CD30, CD38, HLA-DR), functional markers of cytotoxicity (Granzyme B and Perforin ...

Nov 26, 2009 · Our data indicate that CD7 and CD56 coexpression discriminates NK cells from CD7(neg)CD56+ monocyte/DC-like cells, thereby improving our ability to study the intricacies of NK-cell subset phenotypes and functions in vivo.

5 days ago · Within the T and NK cluster, ... OVA.Il12 and OVA.Combo reduced the fraction of Th2-skewed Il4 CD4 + T cells and increased ... T cell memory phenotype development (KLRG1, CD7, P2RX7), and T cell ...