Jul 10, 2023 · Through CRISPR-Cas9 and proteomics screens, we identify and validate CMTM6 as critical for CD58 stability and upregulation of PD-L1 upon CD58 loss. Competition between CD58 and PD-L1 for CMTM6 binding determines their rate of …

CD58, lymphocyte-function antigen 3 (LFA-3), is a glycoprotein that plays a vital role in the body's immune response. The natural ligand to CD58, CD2, is most commonly found on the surfaces of both T cells and Natural Killer cells (T/NK cells). [3]

Jun 15, 2023 · We show that CD58 is crucial for infiltration of tumors by T cells, likely via its adhesive properties when ligated with CD2, and that increased CD58 co-stimulatory signaling via CD2 can enhance T cell activation and cytotoxicity.

May 19, 2022 · A preprint by Ho et al. investigates the role of decreased CD58 expression in cancer cell immune evasion, through both lack of T cell co-stimulation and increased T cell inhibition.

In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a …

Nov 5, 2024 · Evidence suggests the CD2:CD58 axis is crucial for the efficacy of chimeric antigen receptor (CAR) T cells. CD58 loss in cancer cells leads to CAR T cell resistance and CD2-dependent T cell engagement in the tumor microenvironment is …

Sep 14, 2020 · CD2–CD58 interactions in the corolla boosted signaling by 77% as compared with central CD2–CD58 interactions. Engaged PD-1 invaded the CD2 corolla and buffered CD2-mediated amplification of TCR...

Dec 11, 2023 · CD58 is a co-stimulatory molecule on antigen-presenting cells and target cells that binds CD2 on T and NK cells to provide adhesion and a secondary signal for immune cell activation, in...

Jul 15, 2015 · Blocking CD58 mAb greatly reduced the response of human CD28 (-)CD8 (+) T cells to allogeneic dendritic cells, as well as to viral Ags. Our results clearly identify the CD58/CD2 axis as the primary costimulatory pathway for CD8 T cells that lack CD28.

Jun 11, 1999 · Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells optimizes immune recognition, facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells.