CD58, lymphocyte-function antigen 3 (LFA-3), is a glycoprotein that plays a vital role in the body's immune response. The natural ligand to CD58, CD2, is most commonly found on the surfaces of both T cells and Natural Killer cells (T/NK cells). [3]

In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a …

Jun 15, 2023 · We show that intact cancer cell CD58 expression is required for effective T cell-mediated anti-tumor responses, and that loss of CD58 confers cancer immune evasion through multiple mechanisms, including impaired activation and proliferation of T cells; reduced tumor lytic capacity, tumor infiltration, and intratumoral T cell expansion; and ...

May 19, 2022 · CD58 -knockout tumours were more resistant to TILs and had significantly lower rates of T cell infiltration and proliferation compared with wild-type tumours. Rescue with CD58 overexpression ...

Jun 8, 2021 · The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells.

Mar 28, 2025 · CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Hematologic Cancer and Paroxysmal Nocturnal Hemoglobinuria. Among its related pathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

Nov 2, 2023 · CD58 downregulation suppressed the negative regulation of the LYN/CD22/SHP1 axis, thereby promoting the activation of JAK2/STAT1 and upregulating PD-L1 and IDO expression.

Nov 22, 2022 · We found that disruption of CD58 in tumor cells induced the formation of suboptimal immunological synapse (IS) with CAR T cells, which conferred functional impairment of CAR T cells, including the attenuation of cell expansion, degranulation, cytokine secretion, and …

We further discovered co-regulation of co-stimulatory (CD58) and co-inhibitory (PD-L1) cancer cell signals by the stabilizing molecule CMTM6. Altogether, this study emphasizes the importance of cancer cell-intrinsic expression of CD58 for cancer immunity.

The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers published in Cancer Cell, Miao et al. and Ho et al. define a mechanism of CD58 regulation by CMTM6 and …