Nov 3, 2022 · We performed unbiased genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screening using 2 ATLL-derived cell lines and discovered CD48 as one of the best-enriched genes whose knockout conferred resistance to YT1-NK cell line-mediated cytotoxicity.

CD244:CD48 interactions regulate target cell lysis by NK cells and CTLs, which are important for viral clearance and regulation of effector/memory T cell generation and survival. Here we review roles of CD48 in infection, tolerance, autoimmunity, and allergy, as well as the tools used to investigate this receptor.

CD48 antigen (cluster of differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.

Sep 11, 2017 · IrAPs expressed NKG2D ligands and CD48, and coengagement of CD16 with NKG2D and 2B4 caused potent NK cell activation and proliferation. The expanded NK cells were cytotoxic toward various...

Feb 14, 2024 · CD48 mediates ADCC sensitivity by regulating NK activity. To establish whether CD48 loss downregulates NK activity leading to ADCC resistance, we generated CD48-KO cells using CRISPR, and...

Nov 5, 2024 · While high CD48 expression in solid tumors often links to poor prognosis, its role in hematological malignancies is less clear. CD48 is believed to activate NK cells, and its absence may impair NK cell function, though this is not well elucidated.

CD48 binds to CD2 and is involved in a wide variety of innate and adaptive immune responses, ranging from granulocyte activity and allergy to T cell activation and autoimmunity, and CTL or NK function and antimicrobial immunity. 9 CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been ...

Nov 3, 2022 · Whole-genome CRISPR library screening identified CD48 as a key molecule to define susceptibility to NK-cell–mediated cytotoxicity in ATLL. ATLL and other PTCLs had reduced CD48 expression compared with normal T cells, implicating a role of reduced CD48 in PTCL pathogenesis.

Nov 5, 2024 · While high CD48 expression in solid tumors often links to poor prognosis, its role in hematological malignancies is less clear. CD48 is believed to activate NK cells, and its absence may impair NK cell function, though this is not well elucidated.

Jul 1, 2004 · We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on NK cells and CD48 on T cells.