Nov 3, 2022 · We performed unbiased genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screening using 2 ATLL-derived cell lines and discovered CD48 …

It was found that the preferred ligand of CD48 is 2B4 (CD244), which is also a member of the CD2 subfamily SLAM of IgSF expressed on natural killer cells (NK cells) and other leukocytes.

CD244:CD48 interactions regulate target cell lysis by NK cells and CTLs, which are important for viral clearance and regulation of effector/memory T cell generation and survival. Here we …

Nov 5, 2024 · This suggests that increased CD48 expression might impair NK cell immunosurveillance of MM, contrary to cell line-based CRISPR screens indicating CD48 can …

Feb 14, 2024 · We found that KDM6A epigenetically upregulates the expression of CD48 in MM cells, whereas loss of CD48 has a known role in the evasion of NK cell-mediated surveillance …

Nov 3, 2022 · Whole-genome CRISPR library screening identified CD48 as a key molecule to define susceptibility to NK-cell–mediated cytotoxicity in ATLL. ATLL and other PTCLs had …

Feb 14, 2024 · Inhibition of H3K27me3 with an EZH2 inhibitor resulted in CD38 and CD48 upregulation and restored sensitivity to Daratumumab.

SLAM-related receptors (SRRs) are important modulators of immune cell function. While most SRRs are homophilic, 2B4 (CD244) interacts with CD48, a GPI-anchored protein expressed …

Jul 1, 2004 · We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on …

Li et al. demonstrate that the 2B4-CD48 axis suppresses phagocytosis of adaptive NK cells by activated macrophages during MCMV infection by inhibiting the pro-phagocytic integrin LFA-1 …