CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. [5] …

Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b …

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediate d injury by cleaving C3b and C4b deposited on host tissue. May …

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b …

Two features make CD46 an attractive target for oncology applications: (1) it is overexpressed on many cancer cell types and (2) measles and adenoviral vectors can be constructed to target …

CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. CD46 is also used as a receptor by several …

CD46 not only protects cells from complement-mediated attack and facilitates infection by a large number of pathogens, but also exerts complex effects on cellular immune function.

Sep 30, 2010 · CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage. Recent data show that …

Jun 10, 2015 · Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I …

Mar 28, 2025 · CD46 (CD46 Molecule) is a Protein Coding gene. Diseases associated with CD46 include Hemolytic Uremic Syndrome, Atypical 2 and Genetic Atypical Hemolytic-Uremic …