Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b …

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. [5] …

Hand-in-hand with better understanding of the role of CD46 in endothelial biology as protector of the vascular space against unwanted complement deposition came the realization that the …

May 21, 2019 · Membrane-bound complement regulatory proteins (mCRPs), such as CD46, CD55, and CD59, are expressed throughout the body in order to prevent over-activation of the …

Dec 2, 2016 · Conclusion: We have identified a novel functional antigen, CD46, for ADC targeting of MM, with unique potential for high-risk and relapsed/refractory disease that has genomic …

Nov 1, 2016 · Complement pathway gene expression is variable across acute myeloid leukemia samples. Complement regulator genes are implicated in poor outcome in patients with acute …

Feb 3, 2017 · In this review, we summarize those AML targets for which bispecific antibodies have been developed, in descending order of clinical relevance: CD33, CD123, Wilms’ tumor …

In this report, we show that an anti-CD46 ADC (CD46-ADC) potently inhibited proliferation in myeloma cell lines with little effect on normal cells. CD46-ADC also potently eliminated …

Jul 30, 2024 · Results showed that both CD46 and CD55 were significantly downregulated by 2 to 7 folds in ALL and AML patients compared to healthy controls. The determined downregulation …

Nov 9, 2023 · An antibody–drug conjugate (ADC) targeting CD46 conjugated to monomethyl auristatin has a potent anti-myeloma effect in cell lines in vitro and in vivo, and patient samples …