CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). [9] CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signalling.

2 days ago · CD45 is a ubiquitous cell surface marker of nucleated hematopoietic cells involved in the regulation and activation of the immune system

CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

CD45 is a protein found on the surface of most cells in the immune system, including white blood cells (also called leukocytes). CD45 helps these immune cells communicate and respond appropriately to infections and inflammation.

Mar 11, 2025 · Explore the function of CD45 in immune regulation, its role in T-cell signaling, and its diagnostic relevance in hematology. CD45 is a crucial protein on most immune cells, functioning as a phosphatase that regulates signaling pathways controlling immune responses.

CD45 is an essential protein on the surface of cells of the haematological and immunological systems. It has been used as a diagnostic tool to identify cells of haematological origin, but its function and structure are not widely understood. This review aims to …

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and …

Apr 1, 2018 · CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and the developmental or activation status of the cell.

CD45, a receptor-like protein tyrosine phosphatase (PTP), plays an essential role in lymphocyte development and immune responses. Recent evidence suggests that dimerization of CD45 down-regulates its function.

CD45 is a transmembrane glycoprotein that is located on the surface of all leukocytes and modulates both innate and adaptive immune system functions. In a recent study, inflammation modulated the CD45 expression in leukocytes, but the …