The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and …

CD44 and receptor for HA-mediated motility (RHAMM) are the two main HA-receptors whose biological functions in human and murine inflammations and tumor cells have been …

Oct 6, 2020 · Our results revealed that an ER-CD44-HA signaling circuit that mediates robust compensatory activation of the Src-ERK signaling cascade may contribute to the development …

May 10, 2018 · Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the …

In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) …

May 1, 2017 · HA is used by several investigators as a vehicle to transport anticancer drugs for at least three reasons. First, HA binds CD44 variants. Second, HA-drug conjugate is …

Apr 8, 2025 · The CD44-HA binding level varies in different malignancies. Besides, different alternatively spliced variants of CD44 have shown conflicting effects on the development of …

May 6, 2015 · CD44 and receptor for HA-mediated motility (RHAMM) are the two main HA-receptors whose biological functions in human and murine inflammations and tumor cells have …

21 hours ago · HA binds specifically to the overexpressed CD44 receptor on the tumor surface, ensuring that the carrier targets tumors selectively. The incorporated 131 I emits β rays, which …

5 days ago · Similarly, HA-conjugated PTX-N-hydroxy succinimidyl ester and HA-SN-38 (a CPT11 (irinotecan) metabolite) used in cell lines expressing CD44 (colon, breast, stomach, and …