The CD44 antigen is a cell -surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on chromosome 11. [5]

Mar 28, 2025 · CD44 (CD44 Molecule (IN Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Hematologic Cancer and Congenital Dyserythropoietic Anemia. Among its related pathways are Glycosaminoglycan metabolism and Innate Immune System.

Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the potential for targeting CD44 for cancer therapy.

In general, CD44 molecules have seven sites available for N-linked and O-linked glycosylation. CD44 has been shown to bind to hyaluronic acid, heparin sulfate, collagen, and fibronectin (all components of the extracellular matrix) and several cytoskeletal proteins.

Jan 1, 2003 · CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.

CD44 is a prominent activation marker which distinguishes memory and effector T cells from their naïve counterparts. It also plays a role in early T cell signaling events as it is bound to the lymphocyte-specific protein kinase and thereby enhances ...

Mar 7, 2017 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …

CD44 is a multifunctional receptor involved in cell-cell and cell-ECM interactions, cell traffic, lymph node homing, presentation of chemokines and growth factors to traveling cells, and transmission of growth signals.

Increasing evidence suggests that some CD44 isoforms are promising prognostic biomarkers and therapeutic targets for many cancers. This review summarises current insights on CD44 structure and isoforms as well as the CD44-mediated oncogenic signalling pathway in several cancers.

Aug 3, 2020 · CD44 is a cell-surface adhesion receptor associated with many biological processes that rely on cellular plasticity. Now, CD44 has been shown to mediate endocytosis of iron-bound...