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CD43, also known as sialophorin, is a transmembrane cell surface protein. It is differentially expressed in leukocytes, including innate and adaptive immune cells. CD43 participates in T cell adhesion to vascular endothelial cells and contributes to the progression of experimental autoimmunity. In humans, CD43 is encoded by the SPN (sialophorin) gene.
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CD43 - Wikipedia
Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (s ialo p hori n) gene.
Wikipedia
https://en.wikipedia.org/wiki/CD43
Sialomucin CD43 Plays a Deleterious Role in the Development of ...
Sialomucin CD43 is a transmembrane protein differentially expressed in leukocytes that include innate and adaptive immune cells. Among a variety of cellular processes, CD43 partici…
Frontiers
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.780854/full
Wikipedia
Frontiers
Wikipedia
https://en.wikipedia.org/wiki/CD43
CD43 - Wikipedia
Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (s ialo p hori n) gene.
Frontiers
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.780854/full
Sialomucin CD43 Plays a Deleterious Role in the Development of ...
Sialomucin CD43 is a transmembrane protein differentially expressed in leukocytes that include innate and adaptive immune cells. Among a variety of cellular processes, CD43 partici…

GeneCards
https://www.genecards.org › cgi-bin › carddisp.pl
SPN Gene - GeneCards | LEUK Protein | LEUK Antibody
Mar 30, 2025 · [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. ( LEUK_HUMAN,P16150)
Wikipedia
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CD43 - Wikipedia
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Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
6693 - Gene ResultSPN sialophorin [ (human)] - National Center …
CD43 promotes cells transformation by preventing merlin-mediated contact inhibition of growth. We conclude that CD43 is an adverse prognostic marker in DLBCL, and is preferentially …
ScienceDirect
https://www.sciencedirect.com › ...
CD43 - an overview | ScienceDirect Topics
CD43 is a sialomucin transmembrane molecule expressed at high levels on all leukocytes except most resting B lymphocytes. In hematopathology, CD43 is often considered as a T-cell …
Springer
https://link.springer.com › referenceworkentry
CD43 - SpringerLink
Jan 1, 2018 · CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
CD43 Promotes Cells Transformation by Preventing …
Here we provide evidence that the CD43 sialomucin cooperates with oncogenic signals to promote cell transformation by abrogating the contact inhibition of growth through a molecular mechanism that involves AKT-dependent Merlin …
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What is the role of CD43 in cell development?
CD43 signals help the cell progress toward differentiation and maturation, as it regulates cell migration and cell contact.
CD43 - SpringerLink
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Is CD43 a hematopoietic cell molecule?
CD43 is a type I cell surface glycoprotein abundantly expressed on almost all hematopoietic cells, except for erythrocytes and resting B cells. Although initially considered an immune cell molecule, recent reports evidence a much broader distribution, as epithelial cells, and a range of tumors of epithelial origin are CD43 positive.
CD43 - SpringerLink
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Is CD43 a marker for T-cells?
CD43 is a marker expressed by over 95% of thymocytes and peripheral blood T-cells. It is a sialomucin transmembrane molecule expressed at high levels on all leukocytes except most resting B lymphocytes. In hematopathology, CD43 is often considered as a T-cell associated marker.
CD43 - an overview | ScienceDirect Topics
sciencedirect.com
Does CD43 induce apoptosis?
Depending on the cell model, CD43 has been reported to induce apoptosis (Jurkat cells and bone marrow) or, on the contrary, to promote cell survival (T and B lymphocytes). CD43 is only expressed on a small proportion of naive B cells; however, its expression is upregulated upon stimulation and it contributes to cell proliferation.
CD43 - SpringerLink
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Does CD43 act as an antiadhesive molecule?
CD43 –/– leucocytes show enhanced homotypic adhesion and enhanced rolling and adhesion after chemotactic stimuli, indicating that CD43 acts as an antiadhesive molecule inhibiting T cell interactions. This includes an inhibition of T cell killing and an increase in the threshold for T cell activation.
CD43 - an overview | ScienceDirect Topics
sciencedirect.com
Is CD43 expressed in mantle cell lymphoma?
CD43 may be expressed in mantle cell lymphoma and other types of B-cell lymphomas, mastocytosis, some cases of plasma cell disorders, and blastic plasmacytoid dendritic cell neoplasms.
CD43 - an overview | ScienceDirect Topics
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PubMed
https://pubmed.ncbi.nlm.nih.gov
CD43 gene expression is mediated by a nuclear factor which binds ...
Jun 1, 2000 · CD43 is a leukocyte-specific surface molecule which plays an important role both in adhesion and signal transduction. We have identified a site spanning nucleotides +18 to +39 …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
SPN sialophorin [Homo sapiens (human)] - Gene - NCBI
This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, …
nih.gov
https://www.ncbi.nlm.nih.gov › pmc › articles
CD43 gene expression is mediated by a nuclear factor which binds ...
Jun 6, 2000 · CD43 is a leukocyte-specific surface molecule which plays an important role both in adhesion and signal transduction. We have identified a site spanning nucleotides +18 to +39 …
American Society of Hematology
https://ashpublications.org › blood › article
Leukosialin (CD43) defines hematopoietic progenitors in human …
Sep 15, 2006 · We demonstrate that hESC-derived hematopoietic progenitors could be identified by surface expression of leukosialin (CD43). Selection of CD43 + cells reliably separated …
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