Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene. [5] [6] [7]

Mar 19, 2024 · Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)

CD43 is a sialomucin transmembrane molecule expressed at high levels on all leukocytes except most resting B lymphocytes. In hematopathology, CD43 is often considered as a T-cell associated marker, because it is expressed by over 95% of thymocytes and peripheral blood T-cells.

Oct 22, 2009 · CD43-deficient cells exhibited reduced levels of promyelocytic nuclear bodies and had increased sensitivity to apoptosis induced by growth factor withdrawal or T-regulatory cell suppression. Taken together, our data indicate an essential function of CD43 processing and nuclear localization of CD43ct in cell homeostasis and apoptosis.

CD43 is the major sialic acid rich protein on the surface of lymphocytes. However, the specific roles of this protein in different lymphoid cells under normal physiological conditions remain largely unknown.

Jun 13, 2019 · We show here that CD43−/− mice were more resistant to infection due to increased cytotoxicity of antigen specific CD8+ T cells and reduced inflammatory infiltration in the cardiac tissue, both...

CD43 is a highly glycosylated type I transmembrane protein with a mucin-like structure expressed in all immune cells, but mature naïve B lymphocytes.

Jan 1, 2018 · CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, yet the molecule responsible for this immunodeficiency turned out to be WASP.

In a screen designed to identify genes that regulate T cell receptor (TCR)/CD3-mediated apoptosis, we found that high level expression of CD43 protected T cell hybridomas from activation-induced cell death. The protection appears to result from its ...

Sep 24, 2007 · CD43 is a highly glycosylated transmembrane protein expressed on the surface of most hematopoietic cells.