Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD 41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

Apr 1, 2001 · To investigate the precise expression of the CD41 antigen during megakaryocyte (MK) differentiation, CD34 + cells from cord blood and mobilized blood cells from adults were grown for 6 days in the presence of stem cell factor and thrombopoietin. Two different pathways of differentiation were observed: one in the adult and one in the neonate cells.

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation.

Glanzmann thrombasthenia (GT) is a rare autosomal recessively inherited bleeding disorder characterized by the quantitative (type 1 and type 2) or qualitative (type 3) deficiency in platelet membrane glycoprotein (GP) IIb/IIIa (CD41a/CD61) fibrinogen receptors. In type 1, 2, and 3, CD41a/CD61 expression is 5%, 5%–20% and above 20%, respectively.

Invitrogen Anti-CD41a Monoclonal (HIP8), eBioscience™, Catalog # 14-0419-82. Tested in Immunohistochemistry (IHC) and Flow Cytometry (Flow) applications. This antibody reacts with Human samples.

May 30, 2013 · Integrin CD41, thought to absent on adult HSCs, marks a novel subset of myeloid-biased long-term HSCs that becomes prevalent with age. Loss of CD41 leads to transplantable hematopoietic defects that affect HSC survival and maintenance and are, in …

May 12, 2011 · CD41 expression is associated with the earliest stages of mouse hematopoiesis. It is notably expressed on some cells of the intra-aortic hematopoietic clusters, an area where the first adult-repopulating hematopoietic stem cells (HSCs) are generated.

Feb 14, 2025 · CD4 + TLs required large numbers of CD41a + EVs for activation, whereas monocytes were the most sensitive. With the new multi-omics technique, we confirmed the direct effects of CD41a + EVs on protein phenotype and gene activation.

Feb 14, 2025 · We investigated interactions with CD41a-expressing EVs and the resulting cell activation in CD4 + TLs, monocytes, and BLs cultured for 18 h in the presence or absence of purified CD41a + EVs at a ratio of 1:20 (cells: EVs).

Invitrogen Anti-CD41a Monoclonal (eBioMWReg30 (MWReg30)), eBioscience™, Catalog # 12-0411-82. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Mouse samples. Supplied as 100 µg purified antibody (0.2 mg/mL).