T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4.

Jul 1, 2021 · We show that IL-21-CD40-B cells polarize to Ab-secreting plasma cells, whereas IL-4- and Combo-CD40-B cells are mostly activated mature B cells that express molecules …

Jul 1, 2021 · We show that IL-21–CD40–B cells polarize to Ab-secreting plasma cells, whereas IL-4– and Combo-CD40–B cells are mostly activated mature B cells that express molecules …

Feb 13, 2020 · Herein, we report that the combination of agonistic anti-CD40, IL-4 and IL-21 affords polyclonal B cell stimulation that was comparable to R848 and IL-2 for detection of …

Herein, we report that the combination of agonistic anti-CD40, IL-4 and IL-21 affords polyclonal B cell stimulation that was comparable to R848 and IL-2 for detection of influenza-specific …

Mar 29, 2001 · To test this, naive B cells were cultured with anti-CD40 monoclonal antibody (mAb) and IL-4 and, after various times, these stimuli were removed and the cells re-cultured with or …

Aug 15, 1998 · We found that IL-4 and anti-CD40 synergized to induce NF-κB activation and IL-6 production as well as IgE secretion, suggesting that these regulatory events may be involved …

We sought to discover the mechanisms explaining increased IgE production seen at low cell densities when IL-21 is added to human B cell cultures activated with anti-CD40 and IL-4. …

Effect of BCR stimulation and CD40+IL4R ligation on viability of CLL cells and normal B cells. We then examined the biological relevance of BCR stimulation and CD40+IL4R ligation, with and …

Jun 16, 2021 · To further understand these cytokines in CD40-B cell biology, we stimulated CD40-B cells with IL-4 or IL-21 or both (Combo) and characterized the proliferation, subsets, and …