Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

CD40 is a potent stimulator of the immune system and, as such, CD40/CD40L interaction on immune cells has been extensively studied for its involvement in the development of protective anti-tumor immunity.

CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate.

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

Mar 28, 2025 · CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Agammaglobulinemia, X-Linked. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

Feb 15, 2019 · Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies.

Mar 1, 2021 · CD40, also known as Bp50 and TNFRSF5, is a type I membrane glycoprotein with a 62 amino acid (aa) cytoplasmic tail, a 22 aa transmembrane domain and a 173 aa extracellular domain in human. It was first discovered in 1987 as a 50-kDa protein expressed on B cells which regulates B cell proliferation (Ledbetter, Shu, Gallagher, & Clark, 1987 ...

Mar 13, 2025 · CD40 signaling is essential for B and T cell communication, ensuring adaptive immunity functions effectively. When CD40 on B cells binds to CD40L on activated T helper cells, it triggers molecular events that enhance B cell survival, proliferation, and differentiation.

This article reviews recent developments in this field of research, with main emphasis on (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types; and (4) in vivo functions of CD40/CD40-L interactions.

Nov 1, 2008 · CD40 has a rich history as a prominent immune cell activator. 1 CD40 is best known as the key mediator of B lymphocyte immunoglobulin class switch. It also serves as a major activator of antigen-presenting cells, such as macrophages and dendritic cells.