
022071 - CD4Cre Strain Details
022071 B6.Cg-Tg (Cd4-cre)1Cwi/BfluJ <p><strong>This strain ships with remnant UID MiniMax microchips implanted subcutaneously in the back.
Immunologic Applications of Conditional Gene Modification …
CD4-Cre deletes floxed sequences in both CD4 and CD8 T cells. To delete floxed genes only in peripheral CD8 but not CD4 T cells, CD8a–Cre (Maekawa et al., 2008), also known as …
Efficient CD4-Cre mediated conditional KRas expression in alveolar ...
We propose that caKRas-CD4Cre mice represent a novel model of proliferative pneumonia involving macrophages and epithelial cells, and that the CD4Cre model may offer unique utility …
Chromosomal localisation of the CD4cre transgene in B6·Cg-Tg(Cd4-cre …
Sep 1, 2016 · Here we describe a dose-dependent effect of continued CRE recombinase expression on CD4 + T cell numbers and frequencies in the spleen, provide the location of the …
022356 - CD4CreER [T2] Strain Details
022356 B6 (129X1)-Tg (Cd4-cre/ERT2)11Gnri/J This CD4CreER<sup>T2</sup> mutant mouse strain, carrying a transgene with tamoxifen-inducible Cre recombinase under the control of the …
Generation of CD4CreERT2 transgenic mice to study development …
To study molecular mechanisms of peripheral CD4-T-cell differentiation in-vivo and in-vitro we generated transgenic mice expressing a tamoxifen inducible Cre recombinase (CreER T2) …
Cd4-cre Transgenic | Taconic Biosciences
The CD4-Cre Microinjected Mouse uses the mouse Cd4 promoter/enhancer/silencer, which first allows expression of CD4 as thymocytes enter the double positive stage. The silencer region …
A Cre-driven allele-conditioning line to interrogate CD4
Oct 12, 2021 · In the CD4 Cre line, Cre recombinase is under the control of the Cd4 enhancer, promoter, and silencer, and results in Cre-mediated targeting in all T cell populations as the …
Hidden Caveat of Inducible Cre Recombinase: Immunity
Oct 15, 2019 · Lineage-specific Cre drivers (e.g., CD4-Cre for T cells, CD19-Cre for B cells) are often used to restrict effect of Cre to cell types of interest. However, developmental effects of …
Chromosomal localisation of the CD4cre transgene in B6·Cg-Tg (Cd4-cre …
Here we show that CRE recombinase expression reduces the number and frequencies of CD4 positive subsets in a dose-dependent manner and localize the integration site of the transgenic …